I'm not sure if this is related. Checking PYTHONHOME and PYTHONPATH, both are unset in my environment. Additionally, as per my follow-up, it seems to be related to the encoding being stripped from the LC_* variables when MacVim is launched directly (as opposed to being opened from a terminal where the LC_* variable are set correctly). I see terminal apps have the option to set text encoding, not sure if it's possible to configure that in MacVim.
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